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. 2011 Jan 13;20(7):1315–1323. doi: 10.1093/hmg/ddr014

Figure 3.

Figure 3.

Lens cell proliferation was reduced in Nf1−/− mutants. (A–D) Lack of apoptosis defects in Nf1-null lens. Normal TUNEL staining in the Nf1 mutant surface ectoderm at E9.5 (arrowheads) as well as in the invaginating surface ectoderm at E10.5 (insets). (E–H) Cell proliferation quantified as the ratio of BrdU-positive cells versus total DAPI-positive cells in the E9.5 surface ectoderm (arrowheads) and E10.5 lens vesicle (insets). (I) Significant reduction in lens cell proliferation in Nf1 mutants compared with wild-type at E10.5 (P < 0.05; n = 4). Scale bar: 50 μm.