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Induction of Sprouty2 expression and attenuation of ERK signaling during Nf1 lens induction. (A–D) As ERK phosphorylation was up-regulated in the E10.5 Nf1 mutant lens pit, Ras signaling inhibitor Sprouty2 was also induced. (E–H) At E11.5, Nf1 mutant lens exhibited significantly reduced phospho-ERK staining and Erm expression. Scale bars: 50 μm (A–D); 1 mm (E–H).
