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. 2011 Feb 1;121(3):1044–1052. doi: 10.1172/JCI43844

Figure 3. SERCA1 mitigates biochemical and histological features of MD in mdx mice.

Figure 3

(A) H&E- and Masson’s trichrome–stained histological sections from quadriceps of WT, mdx, and mdx-SERCA1 Tg mice at 3 months of age. Original magnification, ×200. (B and D) Percentage of myofibers with centrally located nuclei in mdx and mdx-SERCA1 Tg mice at 6 weeks and 3 months of age. (C and E) Interstitial fibrosis in muscle histological sections analyzed using metamorph analysis software in mdx and mdx-SERCA1 Tg mice at 6 weeks and 3 months of age. Number of mice used for quantitation is shown in the graphs. (F) Quantitation of serum CK levels in mdx and mdx-SERCA1 Tg mice at 3 months of age. *P < 0.05 versus mdx. Number of mice used is shown in the graphs.