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. 2011 Feb 1;121(3):1044–1052. doi: 10.1172/JCI43844

Figure 7. SERCA1 overexpression protects against Ca2+-induced disease indexes in skeletal muscle of Sgcd–/– mice.

Figure 7

(A) Mitochondrial swelling after Ca2+ addition (arrow) as a function of increased light scattering (decreased absorbance) from muscle purified mitochondria from Sgcd+/+, Sgcd+/+-SERCA1 Tg, Sgcd–/–, and Sgcd–/–-SERCA1 Tg mice. (B) Average maximal change in absorbance in response to external Ca2+ in purified mitochondria from the indicated groups. *P < 0.05 compared with Sgcd+/+; #P < 0.05 versus Sgcd–/–. (C) Change in absorbance in response to PEG to show degree of mitochondrial shrinkage in purified mitochondria. *P < 0.05 compared with Sgcd+/+. (D) Calpain enzymatic activity in skeletal muscle of the indicated groups *P < 0.05 compared with Sgcd+/+; #P < 0.05 versus Sgcd–/–. Number of mice used is shown in the bars of each panel.