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. 2011 Feb 21;121(3):1009–1025. doi: 10.1172/JCI44929

Figure 10. MEK inhibitor treatment normalizes cardiac function in L613V/+ mice.

Figure 10

(A) Echocardiographic parameters of hearts after treatment with PD0325901 as described in Figure 9. Note normalization of SV and FS, with a trend toward CO normalization. *P < 0.05, **P < 0.005, ***P < 0.0001, Bonferroni post-test when ANOVA was significant; #P < 0.05, 1-tailed Student’s t test. (B) Hemodynamic parameters, assessed by cardiac catheterization, after PD0325901 treatment. For calculating statistical significance, significant outliers (circled data points), as assessed by Grubbs test, were removed. *P < 0.05, Bonferroni post-test when ANOVA was significant (P = 0.09 including outliers); #P < 0.05, 1-tailed Student’s t test (P = 0.12 including outliers). n = 14 (WT); 10 (L613V/+); 6 (WT PD); 14 (L613V/+ PD).