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. 2011 Feb 14;121(3):1191–1198. doi: 10.1172/JCI45294

Figure 2. The allele frequencies for the rs1137101 allele.

Figure 2

The frequencies are presented for the Q and R alleles. The A nucleotide translates to the amino acid glutamine (Q); the G nucleotide translates to the amino acid arginine (R). International HapMap samples frequencies were 0.53 (Q) for the CEU population and 0.52 (Q) for the GHI. (A) The child cohort is represented by 0, 1–2, or more than 3 infections among all genotyped children in the cohort. The overall allele frequency for the child cohort is 0.52 and 0.49 (Q). Adult ALA patients are subdivided into cases and controls. Parentheses denote the number of alleles for each category. The allele frequencies of the HapMap populations reflect the population-based allele frequencies and are similar to children with 1–2 infections (38). Differences in the allele frequencies are most noted for those with 0 infections, or with more than 3 infections, and the ALA cases. (B) Geographic distribution of the rs1137101 alleles as generated by the Human Genome Diversity Project selection browser ( hgdp.uchicago.edu).