Figure 1.

Actual stemness compared with stemness potential in the skin. LGR5 and LGR6 indicate different stem-cell populations along hair follicles. Stem cells (green), nuclei (grey) and hair follicles (red) are shown in confocal pictures (left) and in the cartoon panels (second from the left). Lineage tracing reveals the actual stemness of a population. LGR5 stem cells generate progeny that repopulate the hair follicle (blue), whereas LGR6 stem cells predominantly generate progeny for sebaceous gland and IFE (blue) and, to a lesser extent, hair follicle (light blue). Transplantation of both stem-cell populations reveals equal stemness potential towards all lineages (blue). EGFP, enhanced green fluorescent protein; IFE, interfollicular epidermis.