Table 3. Amino-acid content in brain extracts from wild-type and Aralar-KO mice at 20 days of postnatal age.
| Brain amino acids | Wild type (nmol/g tissue) | Aralar-KO (nmol/g tissue) (% versus WT) |
|---|---|---|
| Phosphoserine | 431±20 | 540±39* |
| Aspartate | 3006±279 | 429±108*** (14%) |
| Threonine | 388±20 | 340±9 |
| Serine | 1242±69 | 314±33*** (25%) |
| Glutamate | 9335±815 | 7024±455* (75%) |
| Glutamine | 3806±340 | 890±167*** (23%) |
| Glycine | 1863±219 | 1563±174 |
| Alanine | 755±100 | 244±22*** (32%) |
| Valine | 123±5 | 126±24 |
| Isoleucine | 50±2 | 45±9 |
| Leucine | 76±3 | 86±13.1 |
| Lysine | 501±51 | 413±33 |
| GABA | 1358±141 | 1324±207 |
GABA, γ-aminobutyric acid; WT, wild type.
Data are expressed as nmol/g tissue (mean±s.e.m.; n=6–10). Statistical comparisons were performed using one-way analysis of variance followed by post hoc Duncan/Tukey t-test. ***P⩽0.001; *P⩽0.05.