Figure 6.

Salt-induced kinase 1 (SIK1) gene knockdown increased oxygen–glucose deprivation (OGD)-induced neuronal cell death in the presence of the histone deacetylase (HDAC) inhibitor trichostatin A (TSA). Cell death was measured by lactate dehydrogenase (LDH) release at 24 hours reoxygenation. Results are expressed as ratios to maximum release when all cells are killed by triton. ^#P<0.05 versus control neurons (C) without TSA; ^*P<0.05 versus SIK1 small interference RNA (siRNA)-expressing lentivirus (siRNA)-transduced neurons with TSA treatment (n=7).