Figure 3.

Summary of longitudinal 3-hour region of interest (ROI) analysis of CBF_LSF changes after middle cerebral artery occlusion (MCAO) (n=7). (A) Mean ΔCBF_LSF (±s.d.) during first hour after macrosphere injection. In MCAO cases, early ischemic lesion appeared in a concentric manner and ROIs ‘W, V, X, Q, R, S, Y, and T' were severely affected. (B) Grey level coded representation of mean ΔCBF_LSF in respective ROIs during first hour after macrosphere injection. (C) Comparison of mean ΔCBF_LSF of the first, second, and third 1-hour period in seven MCAO cases. (D) The x axis is the mean value of ΔCBF_LSF of the first hour in all ROIs of seven MCAO animals and the y axis is the difference between that of the third hour and the first hour. These show that general CBF_LSF reduction persist during the 3-hour observation period (Figure 3C) and weak, even though significant tendency existed for partial recirculation within the 3-hour time frame, being more prominent in ROIs with severe CBF_LSF reduction in the MCA territory.