Figure 6.
Summary of region of interest (ROI) analysis of cortical spreading depolarization (CSD)-coupled CBFLSF waves (n=8). (A) Schema of a (primary) biphasic CBFLSF response, with segments (‘base,' ‘minimum,' ‘maximum,' and ‘effect') used to describe and analyze the morphology of the wave. (B) Means (±s.d.) of ‘base' and ‘effect' of primary waves (n=7). After passage of the primary wave, CBFLSF decreased particularly in ROIs with severe primary ischemia. (C) Correlation between ‘base' and ‘effect' analyzed in individual ROIs of primary concentric waves, showing CBFLSF increases (positive, ‘compensatory' effects of the waves) in cases with ‘maximum' above base level (maximum>base) and CBFLSF decreases (negative effects of the waves) in cases with ‘maximum' below base level (maximum<base). (D) Correlation between ‘base' and ‘effect' analyzed in individual ROIs of secondary circumferential waves showing, similar to primary waves but less distinct, CBFLSF increases in cases with ‘maximum' above base level (maximum>base) and CBFLSF decreases in cases with ‘maximum' below base level (maximum<base).