Table 1. Summary of results obtained in 14 rats after single macrosphere injection.
| Animal number | Observation time (hours) | Ischemic territory in field of view | Post mortem site of macrosphere | Time point of primary wave appearance after macrosphere injection (minutes) | Total number of CSDs | Mean velocity of CSDs (mm/min) |
|---|---|---|---|---|---|---|
| 1 | 3 | MCAO | MCA (MCA/ACA bifurcation) | 2 | 11 | 3.11 |
| 2 | 3 | Uncleara | ICA | 5 | 4 | 3.88 |
| 3 | 3 | MCAO | MCA (MCA/ACA bifurcation) | 18 | 5 | 3.22 |
| 4 | 3 | MCAO | MCA (MCA/ACA bifurcation) | 6 | 5 | 2.74 |
| 5 | 3 | Multiple lesion | ICA | Unclearb | Unclearb | — |
| 6 | 3 | Uncleara | ACA | 2 | 3 | 3.71 |
| 7 | 3 | PCAO | ICA | 2 | 13 | 3.38 |
| 8 | 3 | MCAO | MCA (MCA/ACA bifurcation) | 2 | 7 | 4.44 |
| 9 | 3 | MCAO | MCA (MCA/ACA bifurcation) | 1 | 14 | 3.75 |
| 10 | 1.4 | MCAO | MCA (MCA/ACA bifurcation) | 2 | 4 | 3.9 |
| 11 | 3 | MCAO | MCA (MCA/ACA bifurcation) | 1 | 8 | 3.84 |
| 12 | 3 | MCAO | MCA (MCA/ACA bifurcation) | 1 | 11 | 3.47 |
| 13 | 3 | Multiple lesion | ICA | Unclearb | Unclearb | — |
| 14 | 1 | PCAO | ICA | 8 | 2 | 3.61 |
| Mean | 4.2 | 8.1c | 3.56±0.96 |
ACA, anterior cerebral artery; CBF, cerebral blood flow; CSD, cortical spreading depolarization; ICA, internal carotid artery; MCAO, middle cerebral artery occlusion; PCA, posterior cerebral artery; PCAO, posterior cerebral artery occlusion; PCOA, posterior communicating artery.
a
Injection of macrosphere caused CBF reduction, which did not remain consistent throughout the observation period. CBFLSF waves appeared in the field of view.
b
Ischemic lesions after macrosphere injection were not homogeneous. CBFLSF waves were observed in the field of view but not clearly confined.
c
Mean of 10 animals observed for 3 hours.