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Toll-like receptor 4 (TLR4) contributes to high-mobility group protein box-1 (HMGB1)-mediated murine ischemic brain injury. The TLR 4 is involved in HMGB1-mediated ischemic brain damage. (A–C) The severity of ischemic injury was assessed using measurements of cerebral water content (A), cerebral infarct size (B), and neurologic impairment scores (C). **P<0.01 versus TLR4+/+; ##P<0.01 versus TLR4−/−, n=6.
