Table 1. Plasma α-MSH concentrations (pg/mL) 24 hours after MCAO and intraperitoneal administration of α-MSH or saline.
Dose of α-MSH | Saline | 100 μg/kg | 500 μg/kg | P-value |
---|---|---|---|---|
Two hours MCAO (median, IQR) | 27.4 (15.4–49.6) | 10.3 (1.9–16.9) | 38.1 (22.5–82.5) | <0.001 |
Three hours MCAO (median, IQR) | 9.6 (6.0–44.4) | 4.8 (3.4–5.9) | 38.2 (29.1–52.1) | 0.002 |
α-MSH, α-melanocyte-stimulating hormone; IQR, interquartile range; MCAO, middle cerebral artery occlusion.
Statistics are by the Kruskal–Wallis H-test.