Skip to main content
. 2010 Aug 18;31(2):658–670. doi: 10.1038/jcbfm.2010.142

Figure 2.

Figure 2

Representative cytokine temporal profiles in microdialysate and plasma. The line graphs illustrate representative data obtained from patient 1. The larger panels (A, C, E, G) illustrate the microdialysate-derived values with 3.5% HAS and crystalloid perfusates. The inset panels (B, D, F, H) show the paired arterial and jugular venous plasma values. Sampling frequency differs between the microdialysate (6 hourly) and the plasma (12 hourly). Timescales on horizontal axes are relative to the beginning of microdialysis. Dashed lines link time points that appear aberrant. For IL1α, IL1β, and IP10, their concentrations in microdialysates are several fold higher than in the corresponding plasma samples. Contrastingly, for IL2, plasma concentrations are higher than for microdialysates. Microdialysate cytokine temporal profiles appear independent of those in plasma. These cytokines are chosen to illustrate that the temporal profiles may show a well-defined peak (IL1α and IP10), high initial values that then decrease, suggesting the downstroke of an earlier peak (ILβ), or stability over the entire monitoring period (IL2), suggesting consistent catheter performance. IL, interleukin; HAS, human albumin solution.