Table 2. Study variables by cognitive diagnosis (NL versus MCI) in the groups with VRh data available.
| Variable | NL (n=17) | MCI (n=7) | P |
|---|---|---|---|
| Age | 69.8±6.9 | 73.4±8.2 | NS |
| Gender (% female) | 53 | 71 | NS |
| MMSE | 29.2±1.0 | 28.6±1.4 | NS |
| FCRP | 7.6±4.4 | 8.0±5.4 | NS |
| % With FCRP >10% | 12 | 57 | 0.02 |
| % With LVH | 6 | 0 | NS |
| PWMH score | (n=16) 0.90 ± 0.85 | (n=6) 1.20±0.40 | NS |
| DWMH score | (n=16) 0.90±0.70 | (n=6) 0.70±0.50 | NS |
| Baseline CO2 (mm Hg) | 39.2±3.1 | 38.7±5.9 | NS |
| mean CO2 increase (mm Hg) | 7.1±1.8 | 6.2±1.4 | NS |
| Volume (% of ICV) | |||
| GM | 54±3 | 54±3 | NS |
| Right hippocampus | 0.20±0.02 | 0.19±0.03 | NS |
| Left hippocampus | 0.20±0.03 | 0.20±0.03 | NS |
| Averaged hippocampus | 0.20±0.02 | 0.19±0.03 | NS |
| CBF (mL per 100 g per minute) | |||
| Global cortical | 60.6±7.7 | 57.8±4.2 | NS |
| Right hippocampus | 58.1±9.4 | 60.3±13.4 | NS |
| Left hippocampus | 57.4±11.8 | 55.3±7.8 | NS |
| Averaged hippocampus | 57.8±9.0 | 57.8±9.4 | NS |
| VRh (% ΔCBF/1 mm Hg CO2) | |||
| Global cortical | 1.0±1.5 | 0.31±1.2 | NS |
| Right hippocampus | 1.4±2.7 | 0.23±2.5 | NS |
| Left hippocampus | 1.5±3.3 | −0.22±1.5 | 0.099 |
| Averaged hippocampus | 1.4±2.7 | −0.05±1.7 | 0.047 |
CBF, cerebral blood flow; DWMH, deep white matter hyperintensities; FCRP, Framingham cardiovascular risk profile; GM, gray matter; ICV, intracranial volume; LVH, left ventricular hypertrophy (on ECG); MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; PWMH, periventricular white matter hyperintensities; VRh, vasoreactivity to hypercapnia.
Values represent mean±s.d.
None of the subjects in the subset had diabetes mellitus or cardiovascular disease.
PWMH and DWMH were measured on the 0–3 Fazekas scale (Fazekas et al, 1987).