Table 2. Up-/downregulated genes in PC-3 cells cultured under contact coculture conditions, identified by cDNA microarray analysis.
| Gene bank accession no. | Gene name | Fold changea |
|---|---|---|
| Upregulated genes in contact coculture conditions | ||
| NM_007115 | Tumor necrosis factor, alpha-induced protein 6 | 5.3 |
| NM_000576 | Interleukin 1-β | 4.4 |
| NM_000963 | Prostaglandin-endoperoxide synthase 2 (COX2) | 4.2 |
| NM_001442 | Fatty acid binding protein 4, adipocyte | 4.0 |
| NM_000600 | Interleukin 6 (interferon, β-2) | 3.7 |
| NM_007028 | Tripartite motif-containing 31 | 3.5 |
| NR_003006 | Small Cajal body-specific RNA 6 on chromosome 2 | 3.4 |
| NM_000064 | Complement component 3 | 3.2 |
| Downregulated genes in contact coculture conditions | ||
| NM_003118 | Secreted protein, acidic, cysteine-rich (osteonectin) | 0.3 |
a
The microarray results of PC-3 cells in the contact coculture were compared with those of cells from the bilayer coculture. The fold change in gene expression that was >3.0 or <0.33 was considered significant.