Table 3. Common (>5%) haematological and non-haematological toxicities (intention-to-treat analysis).
|
Toxicity per cycle (N=212)
|
Toxicity per patient (N=49)
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Adverse events | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
| Anaemia | 57 | 14 | 2 | 4a | 28 | 7 | 1 | 2a |
| Leukopenia | 18 | 18 | — | — | 9 | 9 | — | — |
| Neutropenia | 12 | 14 | 14 | — | 6 | 7 | 6 | — |
| Thrombocytopenia | 51 | 22 | 6 | — | 27 | 11 | 3 | — |
| Asthenia | 43 | 49 | 10 | — | 19 | 21 | 2 | — |
| Anorexia | 57 | 12 | 14 | — | 29 | 6 | 7 | — |
| Nausea | 55 | 14 | 12 | — | 25 | 7 | 6 | — |
| Vomiting | 22 | 8 | 10 | — | 11 | 4 | 5 | — |
| Stomatitis | 39 | 2 | 2 | — | 20 | 2 | 2 | — |
| Diarrhoea | 33 | 6 | 4 | — | 15 | 3 | 2 | — |
| Constipation | 49 | 6 | — | — | 21 | 4 | — | — |
| Neuropathy | 88 | 2 | — | — | 41 | 2 | — | — |
| Hand-foot syndrome | 18 | 2 | — | — | 9 | 1 | — | — |
a
Two patients experienced tumour bleeding.