Table 1. Pattern of vascular leakage in the brains of Naglu mice at different stages of disease.

Naglu mice, age	Cx	Hip	Cb	Md	MB	OB	PS	ST	TH
	EB/Alb	EB/Alb	EB/Alb	EB/Alb	EB/Alb	EB/Alb	EB/Alb	EB/Alb	EB/Alb
3 mo	++/++	++/++	++/+	++/+	+/--	--/--	+/--	+/+	+/+
6 mo	++/++	+/+	++/+	++/+	+/+	--/--	+/+	+/+	+/+
10–12 mo	++/++	+/ +	++/+	++/+	+/+	--/ --	+/+	+/+	+/+

Key: Cx – cerebral cortex, Hip – hippocampus, Cb – cerebellum, Md – medulla, MB – midbrain, OB – olfactory bulb, PS – pons, ST – striatum, TH – thalamus, EB – Evans Blue, Alb – albumin, -- - no leak, + - moderate leak (near abluminal side of the capillaries), ++ - significant leak (at a distance from the capillaries). Note: no vascular leakage was determined in examined brain blood vessels from control mice at 3, 6 or 10–12 months of age.