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. Author manuscript; available in PMC: 2011 Mar 7.
Published in final edited form as: Nature. 2004 Jan 29;427(6973):461–465. doi: 10.1038/nature02229

Figure 3.

Figure 3

Effect of ANT-deficiency on mtPTP activation in liver mitochondria. a, ANT-control and b, ANT-deficient mtPTP activation by ΔP depolarization (FCCP) monitored by mitochondrial swelling. Black trace, no CsA; red trace, with CsA. c, Amount of Ca2+ required per mg of mitochondrial protein to activate the mtPTP and collapse ΔP. d, Western blots of cytochrome c released into the supernatant fraction versus COI retained in the mitochondrial pellet following Ca2+-activation of the mtPTP. e, ANT-control and f, ANT-deficient Ca2+-activation of the mtPTP in the presence of positive and negative effectors.