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. Author manuscript; available in PMC: 2011 Mar 7.
Published in final edited form as: Acta Biomater. 2010 Aug 27;7(1):133–143. doi: 10.1016/j.actbio.2010.08.018

Fig. 3.

Fig. 3

Bioactivity of PEG–PDGF was confirmed by seeding 10T1/2 cells onto modified surfaces. (A) By 48 h 10T1/2 cell proliferation had increased significantly in the presence of PDGF-BB (ANOVA, #P < 0.05). No significant difference between the soluble and bound forms of PDGF-BB indicate that covalently immobilized PEG–PDGF-BB retained its bioactivity. (B, C) Hydrogels with patterned regions of PEG–PDGF-BB demonstrate the utility of spatial control of PDGF-BB. 10T1/2 cells seeded onto these patterned gels were evenly dispersed at 4 h (B), but exhibited increased proliferation on regions patterned with PDGF-BB by 48 h (C).