Fig. 2.

Poxvirus egress. Poxviruses such as vaccinia virus replicate in the cytoplasm producing infectious MV at the viral factory. Some MV are transported by an unidentified motor along microtubules to be enveloped at the TGN or endosomes to become IEV. IEV are transported to the cell periphery by KIF5b, where they engage an unknown myosin for active transport across the cortical actin network, fusion at the plasma membrane, and eventual release.