Table 1. Engraftment of Rin1−/− bone marrow cells.
| Antibody (lineage) | Day 34 | Day 105 | ||
|---|---|---|---|---|
| Wild type (%) | Rin1−/− (%) | Wild type (%) | Rin1−/− (%) | |
| Bone marrow | ||||
| CD19 (B cell) | 18 | 15 | 26 | 25 |
| CD11b (mac/gran) | 26 | 25 | 42 | 41 |
| Ter119 (erythroid) | 14 | 16 | 22 | 27 |
| Spleen | ||||
| CD19 (B cell) | 50 | 52 | 73 | 72 |
| CD11b (mac/gran) | 4 | 4 | 5 | 4 |
| CD3e CD4 (helper T) | 6 | 4 | 7 | 15 |
| CD3e CD8 (cytotoxic T) | 3 | 2 | 8 | 6 |
| Thymus | ||||
| CD4+ CD8− (mature T) | 9 | 9 | 6 | 10 |
| CD4− CD8+ (mature T) | 3 | 3 | 7 | 6 |
| CD4+ CD8+ (immature T) | 80 | 81 | 82 | 82 |
| CD4− CD8− (immature T) | 2 | 2 | 5 | 3 |
CD45.2 wild type or Rin1−/− bone marrow samples were transplanted into lethally irradiated CD45.1 mice. After 34 or 105 days, flow cytometric analysis was performed on bone marrow, spleen and thymus cell suspensions. Data are presented as the percentage of single live donor cells (CD45.2+ 7AAD excluded).