Table 3. Interaction of NAT2 tagSNP (rs1495741) and GSTM1 deletion with cigarette smoking in bladder cancer risk.
Results from logistic regression analyses of aggregated data adjusted by study. rs1495741 genotypes were classified according to an established approach based on the phenotype of NAT2 acetylators; AA/AG were collapsed to tag rapid/intermediate acetylation, and GG tags slow acetylation.26
| Cases |
Controls |
P | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
NAT2 (rs1495741) |
AA/AG | GG | AA/AG | GG | OR | 95% CI | P | Interaction | |
| All subjects | 3,784 | 6,915 | 5,233 | 8,182 | 1.15 | 1.09 | 1.22 | 2.9E-07 | |
|
By smoking
status |
|||||||||
| Never smoker | 760 | 1,202 | 1,679 | 2,758 | 0.95 | 0.85 | 1.06 | 3.3E-01 | Ref. |
| Ever smoker | 3,024 | 5,713 | 3,554 | 5,424 | 1.24 | 1.16 | 1.32 | 4.3E-11 | 6.3E-05 |
| Former smoker | 1,859 | 3,455 | 2,300 | 3,559 | 1.20 | 1.11 | 1.29 | 6.8E-06 | 6.7E-04 |
| Current smoker | 1,165 | 2,258 | 1,254 | 1,865 | 1.27 | 1.14 | 1.40 | 7.2E-06 | 1.6E-04 |
| GSTM1 Del | Present | Null | Present | Null | |||||
|
| |||||||||
| All subjects | 1,319 | 1,995 | 1,717 | 1,726 | 1.47 | 1.33 | 1.62 | 4.4E-14 | |
|
By smoking
status |
|||||||||
| Never smoker | 210 | 346 | 519 | 510 | 1.71 | 1.38 | 2.12 | 6.9E-07 | Ref. |
| Ever smoker | 1,109 | 1,649 | 1,198 | 1,216 | 1.47 | 1.30 | 1.67 | 2.1E-09 | 1.1E-01 |
| Former smoker | 564 | 961 | 622 | 653 | 1.62 | 1.39 | 1.89 | 4.7E-10 | 6.9E-01 |
| Current smoker | 545 | 688 | 576 | 563 | 1.19 | 1.00 | 1.40 | 4.5E-02 | 8.1E-03 |