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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: J Comp Neurol. 2011 Apr 1;519(5):989–1005. doi: 10.1002/cne.22563

Figure 3.

Figure 3

3D reconstruction and comparative ultrastructural analysis of the spine apparatus (SA) in the striatum of normal (n = 3) and MPTP-treated (n = 3) monkeys. A,B: Electron micrographs of vGluT1-immunoreactive axo-spinous synapses in the striatum of control (A) and MPTP-treated (B) monkeys. A1,A2,B1,B2: 3D-reconstructed images of the corresponding glutamatergic axo-spinous synapses depicted in A and B from the striatum of control (A,A1,A2) and MPTP-treated (B,B1,B2) monkeys. The neck (N) and head (H) of the spines are partially transparent to better show and compare the complexity and distribution of the SA between control and MPTP conditions. C: Histogram comparing the relative volume of the SA over the total spine (Spi) volume in vGluT1- and vGluT2- receiving spines in control and MPTP-treated monkeys. Statistical differences were determined by t-test (*, P = 0.032). Scale bar = 1 μm in A,B. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]