Table 5.
Results of polytomous logistic regression (LR) analysis on DNA repair genotypes/haplotypes and selected toxicity categories†
| Gene | Genotype | Patients | Nausea Vomiting | Oral Mucositis | Diarrhea | GI toxicity* | Skin Toxicity | Infections | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No | % | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | ||
| XRCC1 | GG | 137 | 46.8 | 1 | – | 1 | – | 1 | – | 1 | – | 1 | – | 1 | – |
| GA | 123 | 41.9 | 0.90 | 0.56–1.44 | 0.82 | 0.52–1.27 | 0.88 | 0.56–1.38 | 0.88 | 0.56–1.37 | 0.90 | 0.57–1.43 | 0.91 | 0.58–1.44 | |
| AA | 29 | 9.9 | 0.97 | 0.45–2.04 | 1.18 | 0.57–2.44 | 0.85 | 0.41–1.76 | 0.96 | 0.47–1.93 | 0.83 | 0.39–1.71 | 0.76 | 0.35–1.62 | |
| GA or AA | 152 | 0.91 | 0.58–1.43 | 0.89 | 0.58–1.35 | 0.87 | 0.57–1.34 | 0.89 | 0.59–1.36 | 0.89 | 0.58–1.37 | 0.88 | 0.57–1.36 | ||
| XPD | AA** | 125 | 42.7 | 1 | – | 1 | – | 1 | – | 1 | – | 1 | – | 1 | – |
| Lys751Gln | AC | 118 | 40.3 | 0.92 | 0.56–1.49 | 0.77 | 0.48–1.22 | 0.85 | 0.53–1.35 | 0.77 | 0.49–1.23 | 0.98 | 0.60–1.58 | 1.71 | 1.05–2.78 |
| CC | 45 | 15.4 | 0.47 | 0.23–0.94 | 1.20 | 0.64–2.24 | 0.73 | 0.37–1.41 | 0.94 | 0.50–1.77 | 1.33 | 0.70–2.50 | 1.22 | 0.64–2.30 | |
| AC or CC | 163 | 0.77 | 0.49–1.21 | 0.87 | 0.57–1.34 | 0.82 | 0.53–1.26 | 0.82 | 0.53–1.25 | 1.07 | 0.69–1.67 | 1.54 | 0.99–2.43 | ||
| XPD | GG** | 127 | 43.3 | 1 | – | 1 | – | 1 | – | 1 | – | 1 | – | 1 | – |
| Asp312Asn | GA | 113 | 38.6 | 1.04 | 0.63–1.72 | 1.09 | 0.68–1.75 | 1.01 | 0.63–1.62 | 1.11 | 0.70–1.78 | 0.91 | 0.56–1.49 | 1.68 | 1.03–2.76 |
| AA | 37 | 12.6 | 0.38 | 0.17–0.81 | 0.99 | 0.51–1.90 | 0.64 | 0.31–1.33 | 0.83 | 0.42–1.63 | 1.57 | 0.79–3.12 | 1.39 | 0.70–2.76 | |
| GA or AA | 150 | 0.81 | 0.51–1.29 | 1.06 | 0.69–1.64 | 0.91 | 0.58–1.41 | 1.03 | 0.67–1.59 | 1.05 | 0.67–1.65 | 1.60 | 1.02–2.53 | ||
| XPD haplotype | All other | 151 | 55.3 | 1 | – | 1 | – | ||||||||
| D-group | 122 | 44.7 | 1.23 | 0.76–1.97 | 0.87 | 0.56–1.76 | 0.97 | 0.61–1.52 | 0.92 | 0.59–1.43 | 0.86 | 0.54–1.35 | 1.26 | 0.80–2.00 | |
| AA | 105 | 38.5 | 1 | – | 1 | – | |||||||||
| DA | 18 | 6.6 | 0.87 | 0.33–2.26 | 0.86 | 0.34–2.12 | 0.79 | 0.31–1.93 | 0.86 | 0.36–2.11 | 0.59 | 0.22–1.48 | 0.71 | 0.26–1.86 | |
| DC | 85 | 31.1 | 1.08 | 0.61–1.89 | 0.86 | 0.50–1.46 | 0.92 | 0.54–1.57 | 0.91 | 0.54–1.54 | 0.99 | 0.57–1.72 | 1.77 | 1.02–3.11 | |
| Other | 65 | 23.8 | 0.49 | 0.26–0.91 | 1.26 | 0.72–2.21 | 0.79 | 0.43–1.42 | 1.00 | 0.56–1.77 | 1.20 | 0.67–2.15 | 1.38 | 0.77–2.47 | |
| AA | 105 | 38.5 | 1 | – | 1 | – | |||||||||
| DA/AC | 29 | 10.6 | 0.85 | 0.39–1.86 | 1.24 | 0.60–2.59 | 0.99 | 0.46–2.08 | 1.21 | 0.58–2.53 | 0.64 | 0.29–1.39 | 0.94 | 0.42–2.04 | |
| DD/CC/DC | 89 | 32.6 | 1.06 | 0.61–1.85 | 0.82 | 0.48–1.40 | 0.91 | 0.54–1.55 | 0.85 | 0.50–1.43 | 1.08 | 0.63–1.86 | 1.73 | 1.00–3.01 | |
| DB/BC | 26 | 9.5 | 0.57 | 0.24–1.31 | 1.19 | 0.52–2.72 | 0.90 | 0.39–2.05 | 0.97 | 0.42–2.24 | 0.82 | 0.36–1.83 | 1.50 | 0.66–3.39 | |
| BB | 24 | 8.8 | 0.31 | 0.11–0.79 | 1.21 | 0.56–2.61 | 0.53 | 0.21–1.27 | 0.92 | 0.42–2.07 | 1.60 | 0.69–3.68 | 1.30 | 0.57–2.93 | |
†
ORs and 95% CI from polytomous logistic regression models are adjusted for induction treatment regimen and age
*
GI toxicity includes: nausea/vomiting, oral mucositis, diarrhea, esophagitis/dysphagia, other
**
referent genotype