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. Author manuscript; available in PMC: 2011 Mar 8.
Published in final edited form as: J Med Chem. 2008 Aug 8;51(17):5176–5197. doi: 10.1021/jm800113p

Table 3.

Enzyme Inhibition and Whole Cell Data for gem-Dimethyl ethyl enediamine-Based Inhibitors 3a–ea

graphic file with name nihms268902t13.jpg
Compound Inhibition of PfFTase (%) ED50 (nM)
Number R 50 nM 5 nM 3D7 K1
3a graphic file with name nihms268902t14.jpg 100 88 160 55
3b graphic file with name nihms268902t15.jpg 98 91 210 75
3c graphic file with name nihms268902t16.jpg 70 ND 2450 ND
3d graphic file with name nihms268902t17.jpg 87 ND 400 250
3e graphic file with name nihms268902t18.jpg 100 93 180 75
a

ND = not determined.