Table 5.

Enzyme Inhibition and Whole Cell Data for (±)-cis-l,3-Diaminocyclopentane-Based Inhibitors (±)-8a–e and for (±)-trans-l,3-Diaminocyclopentane-Based Inhibitors (±)-9a–e^a

Compound		Inhibition of PfFTase (%)		ED50 (nM)		Compound		Inhibition of PfFTase (%)		ED50 (nM)
Number	R	50 nM	5 nM	3D7	K1	Number	R	50 nM	5 nM	3D7	K1
8a		40	4	700	800	9a		93	65	340	145
8b		24	ND	2400	2600	9b		33	ND	2400	2200
8c		15	ND	2400	2500	9c		56	ND	1500	1200
8d		83	33	300	125	9d		97	86	310	80
8e		6	ND	600	720	9e		38	ND	2600	1500

^aND = not determined.