Kir4.1 immunoreactivity in adult hippocampus in WT (A, C) and AQP4-/- mice (B, D). Note the abundance of astrocytic process immunoreactivity in both CA1 (A, B) and dentate gyrus (C, D) in both genotypes. Apparently, CA1 stratum radiatum (sr) displays more intense immunoreactivity than CA1 stratum lacunosum moleculare (slm) in both genotypes (A, B). Scale bar, 100 μm.
AQP4 immunoreactivity in P9 hippocampus in WT (E) and Kir4.1-/- (F) mice. A similar pattern of AQP4 immunoreactivity is observed with blood vessel and parenchymal immunoreactivity indicating no dramatic effects of Kir4.1 deletion on AQP4 immunoreactivity. Scale bar, 200 μm.