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. Author manuscript; available in PMC: 2012 Mar 31.
Published in final edited form as: Neuroscience. 2011 Jan 26;178:189–195. doi: 10.1016/j.neuroscience.2011.01.043

Figure 6. Effect of repeated stimulation on hyperalgesia for other algesic agents.

Figure 6

The ability of other proalgesic substances to induce stimulation-enhanced hyperalgesia was tested. Prostaglandin E2 (PGE2, 100 ng, panel B), tumor necrosis factor alpha (TNFα, 100 ng, panel C), interleukin-6 (IL-6, 1 ng, panel D), nerve growth factor (NGF, 1 µg, panel E) and glia-derived neurotrophic factor (GDNF, 10 ng, panel F) were administered. Paw withdrawal thresholds were measured at five minute intervals for 15 minutes, starting 15 minutes after administration. Data for the 5 minute interval 30 minute group that received ET-1, shown in Fig. 3B, is replotted in this figure (panel A) for comparison. One-way repeated measures ANOVA showed there was no significant effect of time in any of these experiments: PGE2 (F3,9=0.600; p=0.631), TNF (F3,9=0.225; p=0.804), IL-6 (F3,9=0.007; p=1.000), NGF (F3,9=1.670; p=0.281), GNDF (F3,9=0.659; p=0.510). These results suggest that stimulation-enhanced hyperalgesia is a novel property of ET-1.