Table 1.
Demographic Characteristics of non-demented cohort
| Variable | Cognitively Diagnosis |
|||||
|---|---|---|---|---|---|---|
| a-MCI |
na-MCI | All MCI | Cognitively Normal |
P-value | ||
| n = 241 | n = 88 | n = 329 | n = 1,640 | a-MCI vs. na-MCI | All MCI vs. Normal | |
| Age, median (Q1, Q3)*, years | 82.7 (79.0, 86.0) | 82.5 (78.4, 85.4) | 82.7 (79.0, 85.8) | 79.6 (75.1, 83.6) | 0.60 | < 0.001 |
| Sex, (% men) | 150 (62.2) | 42 (47.7) | 192 (58.4) | 810 (49.4) | 0.018 | 0.003 |
| Education, median (Q1, Q3)*, years | 12 (12, 16) | 12 (12, 14) | 12 (12, 15) | 13 (12, 16) | 0.12 | < 0.001 |
| < 9 years | 35 (14.5) | 13 (14.8) | 48 (14.6) | 92 (5.6) | 0.12 | < 0.001 |
| 9–12 years | 95 (39.4) | 45 (51.1) | 140 (42.5) | 641 (39.1) | ||
| > 12 years | 111 (46.1) | 30 (34.1) | 141 (42.9) | 907 (55.3) | ||
| Stroke, n (%) | 34 (14.1) | 22 (25.0) | 56 (17.0) | 127 (7.7) | 0.020 | <0.001 |
| Coronary heart disease†, n (%) | 83 (34.4) | 38 (43.2) | 121 (36.8) | 489 (29.8) | 0.15 | 0.013 |
| APOE ε4ε4 or ε3ε4‡, n (%) | 70 (31.5) | 19 (22.9) | 89 (27.1) | 334 (20.4) | 0.14 | 0.006 |
| BMI ≥ 30, n (%) | 51 (21.2) | 23 (26.1) | 74 (22.5) | 457 (27.9) | 0.30 | 0.06 |
| Hypertension‡, n (%) | 166 (68.9) | 68 (77.3) | 234 (71.1) | 1154 (70.4) | 0.14 | 0.79 |
| DIABETES | ||||||
| Cigarette smoking (ever) ‡, n (%) | 122 (50.6) | 43 (48.9) | 165 (50.2) | 805 (49.1) | 0.78 | 0.73 |
| Current smoker | 9 (3.7) | 4 (4.5) | 13 (4.0) | 66 (4.0) | 0.74 | 0.95 |
| Former smoker | 113 (46.9) | 39 (44.3) | 152 (46.2) | 739 (45.1) | 0.68 | 0.70 |
| Depression‡, n (%) | 60 (24.9) | 26 (29.5) | 86 (26.1) | 182 (11.1) | 0.47 | <0.001 |
| Systolic blood pressure§‡, median (Q1, Q3) | 136 (124.8, 149) | 136 (120, 149) | 136 (123, 149) | 136 (123, 149) | 0.84 | 0.92 |
| Diastolic blood pressure§‡, median (Q1, Q3) | 70 (63, 78) | 70 (62, 79) | 70 (63, 78.5) | 70 (63, 79) | 0.67 | 0.62 |
| Focal neurological signs‡, n (%) | 21 (8.7) | 15 (17.0) | 36 (10.9) | 67 (4.1) | 0.032 | <0.001 |
| Change in thinking develop after stroke, n (% in those with stroke) | 9 (26.5) | 8 (36.4) | 17 (30.4) | 14 (11.0) | 0.040 | <0.001 |
| Hemiparesis, n (%)‡ | 12 (5.0) | 7 (8.0) | 19 (5.8) | 39 (2.4) | 0.30 | 0.001 |
*
Q1 = 25 percentile, Q3 = 75 percentile
†
Definitive or probable myocardial infarction, coronary artery bypass grafting (CABG), or percutaneous intervention (PCI), probable angina
‡
112 normal, 19 a-MCI, and 5 na-MCI missing APOE data; 33 normal, 7a-MCI, and 4 na-MCI missing BMI data; 1 normal missing hypertension data; 1 normal missing cigarette smoking data; 2 normal missing current smoking data; 50 normal, 9 a-MCI, and 1na-MCI missing depression data; 18 normal, 3 a-MCI, and 1 na-MCI missing both systolic & diastolic blood pressure data; 4 normal missing focal neurological signs data; 4 normal, 1 a-MCI, and 1 na-MCI missing hemiparesis data.
§
blood pressures were the average blood pressures