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. Author manuscript; available in PMC: 2011 Nov 16.
Published in final edited form as: Cancer Cell. 2010 Nov 16;18(5):411–422. doi: 10.1016/j.ccr.2010.10.024

Figure 1. Primary sequence and HDM2/HDMX binding activity of SAH-p53-8.

Figure 1

(A) Composition of wild-type p5314–29, SAH-p53-8, and SAH-p53-8F19A peptides. (B) Direct binding of FITC-peptides to recombinant HDMX as measured by fluorescence polarization. Competition of SAH-p53-8 and Nutlin-3 with FITC-SAH-p53-8 for binding to HDM2 (C) and HDMX (D). mP: units of milli-polarization. Data are mean +/− s.e.m. for experiments performed in at least triplicate.