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. Author manuscript; available in PMC: 2011 Nov 4.
Published in final edited form as: Neuron. 2010 Nov 4;68(3):428–441. doi: 10.1016/j.neuron.2010.10.020

Figure 3.

Figure 3

EC-APP mice show abnormal phenotypes in the elevated plus maze and Y-maze. (A–C) Percent time spent in the open arms of an elevated plus maze was recorded over a 5 min period. At all ages, EC-APP (tTA/tet) mice spent more time in the open arms than the three control groups. *p<0.05, vs. all other groups by ANOVA and Tukey test. (D) All groups spent less and less time in the open arms during subsequent tests, possibly because of aging, habituation to the elevated plus maze, or both. p<0.0001, for effects of genotype and age by 2-way ANOVA. (E–G) EC-APP mice are hyperactive in the Y-maze. Total arm entries were monitored over a 6 min period at 9 (E) and 13 (F) months. Compared with the control groups, EC-APP (tTA/tet) mice showed a trend toward increased activity at 9 months and clear hyperactivity at 13 months. *p<0.05 vs. all other groups by ANOVA and Newman-Keuls post hoc test. (G) None of the groups showed habituation in Y-maze activity during the second exposure. p<0.05 for genotype only by 2-way ANOVA. n=10–13 mice/group. Values are mean ± SEM.