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. Author manuscript; available in PMC: 2012 May 4.
Published in final edited form as: J Med Chem. 2010 Nov 4;53(23):8287–8297. doi: 10.1021/jm100738d

Figure 2.

Figure 2

Binding mode of 14e (green) with (A) HIV-1 wild-type RT (PDB: 3mec) and (B) K103N/Y181C mutant RT (PDB: 3bgr) respectively. Drug 1 (yellow) was superposed into the same pocket for comparison. The hydrogen bonds between the inhibitors and K101 are illustrated with dashed lines (pink). The side chains of key amino acids on the binding site surface are indicated with solid lines (gray).