Table 1.
Baboon | Average BW (kg) | Order of GHB (mg/kg) Conditions | |||||||
---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | ||
AC | 26.5 | S | 3.2 | 10 | 32 | 18^ | 100 | - | - |
DI | 24.0 | S | 3.2 | - | - | - | - | - | - |
PE | 25.7 | S | 10 | 32 | 56 | 100 | - | - | - |
BO | 39.2 | W | 56 | 130v | 178v | 100v | 32 | W | 10 |
CR | 38.3 | W | 32 | 100 | 56 | 78^ | 78 | 10 | - |
DS | 36.0 | W | 32 | 100v | 130v | W | 56v | - | - |
SI | 32.2 | 56 | W^ | 100 | - | - | - | - | - |
JN | 38.8 | 32 | 56 | 100v | 130 | W | - | - | - |
KR | 22.9 | 32 | 56 | W | 10 | 100v | 130v | W | - |
XA | 22.3 | 32 | 56 | W | 56 | 100v | 130^ | - | - |
Indicates dose availability was less than 15 days
S indicates saline vehicle was used
W indicates sterile water vehicle was used
indicates the GHB dose condition was followed by vehicle substitution to evaluate extinction before returning to cocaine baseline