Figure 4.

Kaplan-Meier analysis of declining autoantibody prevalence in the first 12 yr of diabetes. Statistical significance was determined by the Gehan-Breslow-Wilcoxon χ² test, scored as reversion to antibody-negative status on two sequential samples. A, The median persistence of IA2A (dotted line) of 8.5 yr exceeded ZnT8 CWCR (black line) of 6.2 yr (P = 0.026) and GAD (gray line) of 5.7 yr (P = 0.013). B, The median persistence of CWCR (black line) did not differ from that of ZnT8 CR (dotted line) of 5.7 yr or ZnT8 NCW (gray line) of 4.9 yr.