. Author manuscript; available in PMC: 2012 Apr 1.

Published in final edited form as: Biochim Biophys Acta. 2010 Oct 1;1813(4):616–622. doi: 10.1016/j.bbamcr.2010.09.013

Table 1.

Comparison of the channel activities of mPTP, MAC and VDAC^*

	mPTP	MAC	VDAC
Peak conductance (nS)	1.1 ± 0.1	1–5	0.7 ± 0.1
Transition size (nS)	0.3–1.0	0.3–2.0	0.36 ± 0.04
Ion selectivity	Sl. Cation	Sl. Cation	Anion
P_K/P_Cl	7	4.7 ± 1.3	0.7 ± 0.1
Voltage dependent	Yes	No	Yes
Pore diameter (nm)	2.8 ± 0.1	2.7–6.0	2.2 ± 0.05
Physiological Modulators	Ca²⁺, Pi, ADP [16–18]	TBid, Cyt. c [65, 67]	NADH [14, 109]
Pharmacological agents	CsA [49]	iMACs, Bcis [66, 80, 110]	Koenig s Polyanion, G3139, DIDS [36, 111]

The description of the effects on mPTP, MAC and VDAC of the physiological modulators and pharmacological agents cited is given in sections 2 and 3. Sl, slightly; tBid; truncated Bid; Cyt. c, cytochrome c; CsA, cyclosporine A; iMACs, inhibitors of MAC; Bcis, Bax channel inhibitors; DIDS, 4,4′-diisothiocyanatostilbene-2,29-disulfonic acid.