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. Author manuscript; available in PMC: 2012 Jun 30.
Published in final edited form as: Chem Biol Interact. 2010 Oct 8;192(1-2):122–128. doi: 10.1016/j.cbi.2010.09.032

Scheme 2. Conversion of 15-keto PGE2 to 15-keto PGB2.

Scheme 2

Dehydration of 15-keto PGE2 in drug site I of human serum albumin yields a keto-enol tautomer hybrid (15-keto PGA2) that absorbs light at 505 nm. Further rearrangement of the chromophore eventually decays to 15-keto PGB2, which does not absorb light.