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Top and side views of phase I constructs after 4 wks of culture; scale markings are in mm. The 100:0 constructs contracted significantly from the original 5 mm diameter, while serum supplementation led to a spherical morphology. The 75:25 and 50:50 constructs were of similar size. TGF-β1 supplementation led to smaller constructs than IGF-1 supplementation alone or no GF treatment in co-culture constructs.
