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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Semin Cancer Biol. 2010 Oct 12;21(1):35–43. doi: 10.1016/j.semcancer.2010.10.007

Figure 1. Regulators of stellate cell activation and their roles in liver fibrosis and carcinogenesis.

Figure 1

Stellate cells and CAF activated by several factors induce proliferation, invasion and metastasis in hepatocellular carcinoma. TGF-β plays a critical role in liver fibrosis and tumorigenesis through the epithelial-mesenchymal transition.