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. Author manuscript; available in PMC: 2011 Mar 8.
Published in final edited form as: Adv Immunol. 2010;108:111–165. doi: 10.1016/B978-0-12-380995-7.00004-5

Table 2.

Mechanism of t-DC induction Treg phenotype Origin of DC DC phenotype Mechanism of Treg induction Disease Model Reference
Pathologically-induced tolerogenic DC
Pathogen-induced tolerogenic DC
F. hepatica products CD4+CD25+Foxp3+ BMDC i-DC Falcón et al., 2010 (320)

S. japonicum SJMHE1 peptide CD4+CD25+* BMDC i-DC DTH Wang et al., 2009 (321)

C. albicans CD4+Foxp3+IL-10+ BMDC IBD Bonifazi et al., 2009 (322)

Monophosphoryl Lipid A CD4+Foxp3+IL-10+TGFβ+ Oral cavity Oral-m-LC Allam et al., 2008 (323)

LPS CD4+CD25+Foxp3+ BMDC EAU Lau et al., 2008 (324)

Cryptococcus neoformans Glucuronoxylomannan CD4+Foxp3+ BMDC Liu et al., 2008 (325)

Curcuma longa L. products (Curcumin) CD4+CD25+Foxp3+IL10+* BMDC IBD Cong et al., 2009 (208)

Yersinia virulence factor CD4+IL-10+ BMDC Depaolo et al., 2008 (326)

Tumor-induced tolerogenic DC
Pancreatic tumor-derived Mucins * huMoDC Monti et al., 2004 (327)

B16 Melanoma CD4+CD25+Foxp3+* Spleen iDC TGFβ TI Ghiringhelli et al., 2005 (328)

P815 Mastocytoma CD4+IL-10+ Tumor-infiltrating CD4−CD8− TI Liu et al., 2005 (154)

MO4 Carcinoma CD4+IL-10+* Spleen CD4−CD8− TI Zhang et al., 2005 (155)

Necrotic myeloma cells CD4+IL-10+ huMoDC Fiore et al., 2005 (156)

Ovarian carcinoma CD8+CCR7+CD45RO+IL-10+* Ovary ascite pDC CP Wei et al., 2005 (157)

Lung carcinoma cells CD4+CD25+Foxp3+* huMoDC iDC Dumitriu et al., 2009 (158)

Retrocontrol-induced tolerogenic DC
CD8+CD28− suppressor CD4+ huMoDC ILT3+ILT4+ Chang et al., 2002 (329)

CD8+CD28− suppressor CD4+CD45RO+CD25+ huMoDC ILT3+ILT4+ Manavalan et al., 2003 (330)

CD4+ Tregs CD4+* BMDC Martin et al., 2003 (231)