Figure 3.

Potential strategies for targeting tumor stem cells (TSC) include directed attacks at surface antigens, altering the microenvironment and cell-to-cell interactions, inhibiting angiogenesis, targeting embryonic signaling and self-renewal pathways, reversing resistance mechanisms such as ABC transporters, differentiating primitive TSC into more susceptible tumor cells, inhibiting DNA repair, or targeting TSC in unique, cell cycle independent ways like oncolytic virotherapy.