. Author manuscript; available in PMC: 2012 Jan 15.

Published in final edited form as: Bioorg Med Chem. 2010 Dec 16;19(2):735–743. doi: 10.1016/j.bmc.2010.12.030

Table 2.

The GOLDscore Fitness for the GIIA sPLA₂ 2-oxoamide inhibitors based on the α-amino acids.

Compound	IC₅₀ (µM)	Gsc. Fit.
GK126 (S)-Leu	0.30 ± 0.06	85.91
GK145 (R)-Leu	1.75 ± 0.07	84.91
GK111 Gly	4.20 ± 0.20	78.89
GK112	5.60 ± 0.25	77.33
GK122	11.67 ± 0.50	75.69
GK141 (S)-Phe	>1.60	73.09