EtOH dose dependently inhibits AMPAR- and NMDAR-mediated fEPSPs. (A) The effects of 20, 40, and 80 mM EtOH are shown as percent inhibition from the average of baseline and washout. AMPAR-mediated fEPSPs were recorded in the presence of gabazine (10 μM) and AP5 (50 μM) in standard ACSF. In addition, AMPAR-mediated fEPSPs were recorded in Mg2+-free ACSF. Also illustrated is the effect of EtOH on AMPAR-mediated fEPSPs in presence of NASPM, as well as the effect of EtOH on AMPAR-mediated fEPSPs in slices from adult rats. (B) Effect of EtOH on NMDAR-mediated fEPSPs recorded in Mg2+-free ACSF, and NMDAR fEPSPs recorded in 0.5 mM Mg2+ ACSF. *p<0.05, and **p<0.01 by one-sample t-test vs. zero. See text for ANOVA results.