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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Mol Biosyst. 2010 Dec 14;7(3):700–710. doi: 10.1039/c0mb00176g

Figure 1. p97 structure (PDB 3CF1).

Figure 1

A) The overall structure of full length p97 from Mus musculus is shown. One of the protomers is color coded to display the domains; the N-domains are red, the D1 domains are green, the D2 domains are blue, and the N-D1 and D1-D2 linkers are both colored brown. The C-terminal domains were not resolved. This structure was solved in the presence of ATPγS but this is only seen in the D2 domains, the D1 domains are occupied by nucleotide most likely not released during purification. B) The bound nucleotides are shown explicitly in two contiguous protomers in order to illustrate the AAA+-defining structural elements. The elements for both D1 and D2 are shown and colored according to element as follows: the Walker A motifs are red, the Walker B motifs are green, the second regions of homology (SRH) are blue, sensors 1 are yellow and shown as sticks, and sensors 2 (R-fingers) are magenta and also shown as sticks. The N-domains have been colored tan for orientation.