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. Author manuscript; available in PMC: 2011 Mar 8.
Published in final edited form as: Arch Neurol. 2010 Oct;67(10):1238–1250. doi: 10.1001/archneurol.2010.254

Figure 2.

Figure 2

Focal 43-kDa transactivation response DNA-binding protein (TDP-43) pathology. Anti–TDP-43 immunohistochemical examination using phosphorylation-independent (A–F) anti–TDP-43 antibody. A and B, (Trans)entorhinal cortex of a patient with schizophrenia. A, Lack of endogenous TDP-43 staining (“cleared nucleus”) (large arrow) and hardly discernable cytoplasmic TDP-43 immunoreactivity (small arrow) (bar=20 μm) in a neuron. B, Medium-size dense neuronal cytoplasmic inclusions (large arrow) and 2 smaller TDP-43 pathological aggregations (small arrow) (bar=20 μm). C, Large neuronal cytoplasmic inclusion (large arrow) and a cleared nucleus (small arrow) subadjacent to the hippocampal pyramidal cell layer in a subject with schizophrenia (bar=20 μm). D, Skeinlike inclusion in a nigral neuron (large arrow) associated with a cleared nucleus in a patient with schizophrenia (small arrow) (bar=20 μm). E, Neuronal intranuclear inclusion (large arrow) in a cell devoid of the endogenous nuclear staining in the hippocampal CA1 area neuron in an elderly control with mild cognitive impairment (bar=20 μm). Note the presence of normal nuclear staining in surrounding neurons (small arrow).