. Author manuscript; available in PMC: 2011 Mar 8.

Published in final edited form as: Arch Neurol. 2010 Oct;67(10):1238–1250. doi: 10.1001/archneurol.2010.254

Table 2.

Frequency of TDP-43 Pathology in Total Study Cohort and Subjects 65 Years and Older^a

TDP-43 Pathology	No. (%)		P Value^b	No. (%)≥65 y		P Value^b
TDP-43 Pathology	SMI (n=91)	Controls (n=60)	P Value^b	SMI (n=86)	Controls (n=34)	P Value^b
Significant (moderate/severe)	25 (27.5)	10 (16.7)	.12	25 (29.1)	10 (29.4)	.97
Mild	9 (9.9)	2 (3.3)	.72	9 (10.5)	2 (5.9)	.73

Abbreviations: SMI, severe mental illness; TDP-43, 43-kDa transactivation response DNA-binding protein.

Rare/minor TDP-43 pathology (including single dystrophic neurites or cytoplasmic inclusions) was found in an additional more than 20% of both the SMI and control groups, almost exclusively in elderly subjects.

χ² Test (or Fisher Exact test).