Table 3.

Whole-Brain TDP-43 Pathology in Chronic Psychotic Illness and the Controls 65 Years and Older

Case No./Diagnosis	COR	ALL
		PAL		ARC			TRA		NEO				MES		RHO			DEE
	AMY	PAG	PAW	DEG	CAS	ALV	GM	WM	TEG	TEW	FRG	FRW	CIG	CWC	MED	CER	MIB	BAS	THA
1/SMI-D	+	++++
		S>D
2/SMI		++++	++
		S	P											++
3/SMI-D		++++												P, S
		S
4/SMI	++++	++							++				+	+++		++	+
	S	S							S					S		D
5/Control	++	++++													+++	++
	S	S													F>S	S
6/SMI-D		++++	++	+		++	+
		S>D	F			S
7/SMI-D		+++	+				++
		S					S								+++		++
8/Control		+++													F		F
		S
9/SMI-D		+++		+			+++
		S					S
10/SMIa		+++	+				++						++
		S>D					S						S
11/SMI-Db	++	+			+	++++
	S					S												+
12/SMI-D		+				+++
						S			+++
13/Control		+++							S
		S>D
14/SMI-D	+	++		+				+++	+++				+					++	+
		S, D, P						S	D									P
15/SMI-D	+	++					+++
		S					S											+
16/SMI	++					+++	++												+
	D, S					S	S									+
17/Control	+	+++					++				+++
		S					S				S, P
18/SMI-D		+++											+				+++	++	+++
		S															F	D	D
19/SMI						+++		+
						S								++				++
20/SMI-D	++++	++++			+									S				S
	F	D																+
21/SMI-D	++	++++			+		++
	D	D>S					S										+	+
22/SMI		+++			+
		D																++++
23/Control with MCI	+	+++	++	+	++	+	+											P
		D	D		D									+
24/Control with MCI	+++	+++	+	+++	++++	++	++	+
	D	D		D	D	D	D
25/SMI-D		+++
		F>P
26/SMI		+		+++	++++	++	+++	+
				D	D	S	S>D
27/SMI	+	+	+		++++		++	+
					D		F
28/Control			+		+++		++
					D		D>S
29/SMI	+					+	+++	+
							F
30/SMI-D		++++	++++	+		+++	+
		S	P			S
31/Control	++	+++	++++
	D	D>S	P
32/SMI-D	+	+	++++			+
			P
33/Control	++++
	P
34/SMI-D		++	+++				+
		S	P
35/Control			+++
			P

Abbreviations: ALL, allocortex; ALV, alveus; AMY, amygdala; ARC, archicortex; BAS, basal ganglia (striatum/lentiform nucleus); CAS, CA1-CA4–subiculum; CER, cerebellum; CIG, cingulate gray matter; COR, corticoid; CWC, cingulate white matter and corpus callosum; D, diffuse TDP-43 pathology; DEE, deep brain nuclei; DEG, dentate gyrus; F, focal; FRG, frontal gray matter; FRW, frontal white matter; GM, gray matter; MCI, mild cognitive impairment/complaints; MED, medulla; MES, mesocortex; MIB, midbrain; NEO, neocortex; P, perivascular TDP-43 pathology; PAG, periamygdaloid gray matter; PAL, palaeocortex; PAW, periamygdaloid white matter; RHO, rhombencephalon; S, subventricular (subependymal or subpial) TDP-43 pathology; SMI, severe mental illness; SMI-D, severe mental illness with superimposed dementia; TDP-43, 43-kDa transactivation response DNA-binding protein; TEG, temporal gray matter; TEW, temporal white matter; THA, thalamus; TRA, (trans)entorhinal region; WM, white matter; +, rare pathology; ++, mild pathology; +++, moderate pathology; ++++, severe pathology.

^aSchizoaffective disorder.

^bCase with variation in progranulin gene.