Table 4.

Age-Related Frequency of Significant TDP-43 Pathology in Patients With Chronic Severe Mental Illness and Control Subjects

Age Category, y	Significant TDP-43 Pathology in the Hippocampus/(Trans)entorhinal Cortex and/or Amygdala/Periamygdaloid Region
	No. of TDP-43–Positive Cases (n=35)	% of Age Categorya	% of Total Positive Casesa
<64 (n=31)	0	0	0
65–74 (n=31)	4	12.9	11.4
75–84 (n=49)	12	24.5	34.3
≥85 (n=40)	19	47.5	54.3
P valuea		<.001	<.001

Abbreviation: TDP-43, 43-kDa transactivation response DNA-binding protein.

^aχ² Test.