Table 6.1.

Parameters for the combined model given by (6.1). Concentrations are in units of k/μL, and time is measured in days.

Parameter	Description	Estimate
sH	Supply rate of naïve CD4+ T cells	0.0024k/μL day−1
sK	Supply rate of naïve CD8+ T cells	0.0016k/μL day−1
a(t), a0	Antigen stimulation rate, steady state value	a0 = 4%/day
rH	effector CD4+ growth rate upon interacting with positive growth signal	0.33(k/μL)−1 day−1
rK	effector CD8+ growth rate upon interacting with positive growth signal	0.5(k/μL)−1 day−1
rp	Positive signal secretion rate by effector CD4+ cells	100/day
k1	Mass action coefficient for iTreg-suppression of effector cells	20(k/μL)−1 day−1
k2	Mass action coefficient for consumption of growth signal by effectors	2(k/μL)−1 day−1
dH	Effector CD4+ cell death rate	0.23/day
dK	Effector CD8+ cell death rate	0.35/day
dR	iTreg death rate	0.23/day
dp	Positive growth signal decay rate	5.5/day
ε	iTreg differentiation rate from effector cells	0.01/day
Initial concentrations		Values
H0(0)	sH/a0	0.06k/μL
K0(0)	sK/a0	0.04k/μL
H(0)		0 (for simplicity)
K(0)		0 (for simplicity)
p(0)		0 (for simplicity)
R(0)		0 (for simplicity)